The use of intravenous access devices is fundamental for all patients needing frequent blood sample collection, artificial nutrition, chemotherapy, antibiotic therapy, and any other intravenous treatment. This is important both in hospital and home settings. The big news in the last ten years has been the introduction of PICC (Peripherally Inserted Central Catheters) and MIDLINE catheters. These intravenous catheters are used by trained physicians and nurses and the insertion is ultrasound-guided. This manual offers a thorough description of the several clinical settings in which these devices are used and provides clear information on the insertion procedures and management. Also, the authors take into consideration the technical characteristics of the materials, the replacement and removal procedures, as well as how to effectively prevent complications.